Hands-on Guide on Computational Vaccinology and Chimeric Vaccines


About This Course

Why vaccines are important and how Immunoinformatic & Bioinformatics can help us fight pandemics

  • Vaccines are the most cost-effective public health interventions.

  • Vaccines are biological substances that are utilized to stimulate antibody production within the body of an organism to provide active immunity against foreign organisms, mostly viruses and bacteria.

  • Chimeric vaccines are types of recombinant vaccines, produced by substituting genes from the target pathogen in a closely related organism, for similar genes.

  • Chimeric vaccines are useful in studying infectious diseases, including many neglected diseases.

  • Immuno-Bioinformatics is being extensively used in designing B-, T-cell epitopes, vaccines, antibodies, adjuvants, diagnostic kits, and therapeutics.

  • Bioinformatics is also involved in medication development aimed at bio-productive and pharmaceutical/vaccine development.

Case-Study and Real Life Research

In this course, you will be learning how to develop a vaccine against Dracunculus medinesis which causes guinea worm disease in humans.

The video lecture series will take you from the basics such as proteome retrieval of Dracunculus medinesis and all the way to computational development of a chimeric vaccine.

Learning Objectives

Retrieval of Proteome, Antigenicity and Location Prediction
Prediction and Evaluation of cytotoxic T-Lymphocytes (CTL) Epitopes
Prediction and assessment of Helper T-Lymphocytes (HTL) Epitopes
Prediction and assessment of Linear B-Lymphocytes (LBL) Epitopes
Molecular Docking Studies
Estimation of Population Coverage
Mapping of Vaccine Construct
Codon optimization and In Silico Cloning
Immune Simulation
Molecular Dynamic Simulation
Docking between vaccine protein & TLR4 receptor
Screening of B Cell Epitopes Disulfide Engineering of Vannice protein
Tertiary Structure Prediction, Refinement & Validation
Primary & Secondary Structure Prediction & Analysis


  • You don't need any prior Bioinformatics, programming or immunoinformatic knowledge or skills for this course, we'll take care of that and teach you the required topics!
  • Basic immunology background is a plus point, however, if you lack this knowledge, during the course, you'll be taught the basics as well.
  • This course is for both beginners and professionals alike, anyone with biology background can avail this course.

Target Audience

  • The target audience for this Fighting Pandemics: A Complete Guide On Developing Chimeric Vaccines Against Infectious Pathogens workshop are biologists, beginner or intermediate Bioinformaticians or data analysts with no or little experience in applications of computational bioinformatics and bioinformatics pipelines for protein analysis.
  • However, a superficial understanding of molecular biology and immunology is expected from you before you join the course.
  • This hands-on guide will help you properly to understand Immunoinformatic and Bioinformatics, and it is quite easy to get started in, even if you lack a proper understanding of the underlying concepts of Bioinformatics databases, servers, tools and the algorithms working behind them.


19 Lessons

Target Identification

Target Selection3:20
Removing Duplicates3:46
Screening Non-homologous Proteins6:42

Immunoinformatics Approach for Epitope Prediction

Computational Construction of the Vaccine

Molecular Dynamics and Immune Simulation

Supplementary 1

Supplementary 2

Supplementary 3


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All Levels
19 lectures

Material Includes

  • Become a Certified Vaccine Developer
  • Step-by-step pre-recorded lectures
  • Learn any time, any where!
  • Transcription
  • Notes
  • BioPresentations
  • Exercises
  • Certificate

Enrolment validity: 365 days

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